Cardiopulmonary resuscitation (CPR) training is a valuable, life-saving practice. Its main objective is not to treat people but to provide immediate attention to a sick or injured person. Cardiopulmonary resuscitation practice consists of the use of chest compressions and artificial ventilation to maintain circulatory flow and oxygenation during cardiac arrest. Although survival rates and neurologic outcomes are poor for patients with cardiac arrest, early appropriate resuscitation including early defibrillation when needed and appropriate implementation of post–cardiac arrest care lead to improved survival and neurologic outcomes. This CME series is a case-based series dedicated to strengthen and improve the clinical knowledge and skills of primary care practitioners as they serve, support, and deliver care to patients.