Since the SARS-CoV-2 virus first emerged in Wuhan, China in late 2019, its genetic material has experienced numerous changes, some of which have altered how easily it is transmitted, the severity of disease it causes and the performance of COVID-19 vaccines, diagnostics and treatments against it. These changes, or mutations, occur when a virus replicates or makes copies of itself. A virus that has mutated in this way is referred to as a variant. Although some of these changes have no impact on how the virus behaves, others may affect some of its properties such as how easily it is transmitted or its ability to overcome our immune defences. Those changes that are advantageous to the virus tend to spread more, meaning that variants harbouring them gradually replace other circulating variants over time. This CME series uncovers different mechanisms for managing any emergent variant. It is dedicated to strengthen and improve the clinical knowledge and skills of primary care practitioners as they serve, support, and deliver care to covid-19 patients.